Cell & Gene
Cell Culture & Genetic Engineering
Operated by Research Unit 04
Institutional Narrative & Focus
The Cell Culture & Genetic Engineering Unit represents AIMS-PAGE's most advanced translational research capability, bridging fundamental cell biology with applied biotechnology and next-generation therapeutic development. The unit houses BSL-2-rated primary and established cell-culture facilities equipped for mammalian, insect, and plant cell systems. Gene-editing services — anchored by an optimised CRISPR/Cas9 workflow validated across multiple cell types — are supported by molecular confirmation (Sanger, next-generation sequencing) and functional phenotyping. The unit collaborates with pharmaceutical and agricultural clients to produce recombinant proteins, validate biosimilar candidates, and develop model systems for toxicology screening, reducing reliance on animal models and accelerating compound triage.
Scope of Services
Our specific testing configurations, validated chemical assays, and molecular panels:
- Mammalian cell-line establishment
- Recombinant protein expression and purification
- CRISPR/Cas9 genome editing services
- Transfection and viral vector production
- Cell viability, proliferation, and cytotoxicity assays
- Flow cytometry and immunophenotyping
- DNA/RNA extraction and purification
- Gene cloning and recombinant DNA technology
- Protein expression analysis (Western blot analysis)
- Stem cells
- Exosomes
- Target-specific cell antigen (downstream processing)
- Sanger sequencing, DNA barcoding, mutation profiling, SNPs, AFLP
- Gene expression analysis (Conventional PCR, qPCR)
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